Residual striatal dopaminergic nerve terminals in very long‐standing Parkinson's disease: A single photon emission computed tomography imaging study
Identifieur interne : 001408 ( Main/Exploration ); précédent : 001407; suivant : 001409Residual striatal dopaminergic nerve terminals in very long‐standing Parkinson's disease: A single photon emission computed tomography imaging study
Auteurs : Ruth Djaldetti [Israël] ; Mordechai Lorberboym [Israël] ; Yuval Karmon [Israël] ; Therese A. Treves [Israël] ; Ilan Ziv [Israël] ; Eldad Melamed [Israël]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-02-01.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Aged, Brain (metabolism), Brain (radionuclide imaging), Dopamine, Dopamine (metabolism), Dopamine Plasma Membrane Transport Proteins (metabolism), Female, Humans, Male, Middle Aged, Nerve Endings (metabolism), Nerve Endings (radionuclide imaging), Nervous system diseases, Neurons (metabolism), Neurons (radionuclide imaging), Parkinson Disease (metabolism), Parkinson Disease (radionuclide imaging), Parkinson disease, Parkinson's disease, Single photon emission tomography, Tomography, Emission-Computed, Single-Photon, dopamine transporters scan, long standing, single photon emission computed tomography.
- MESH :
- chemical , metabolism : Dopamine, Dopamine Plasma Membrane Transport Proteins.
- metabolism : Brain, Nerve Endings, Neurons, Parkinson Disease.
- radionuclide imaging : Brain, Nerve Endings, Neurons, Parkinson Disease.
- Aged, Female, Humans, Male, Middle Aged, Tomography, Emission-Computed, Single-Photon.
Abstract
Molecular imaging studies of Parkinson's disease (PD) progression mostly focus on the first 5 years after disease onset, demonstrating rapid initial nigrostriatal neuronal loss. The fate of residual functional dopaminergic nerve terminals in patients with long‐standing PD has not yet been specifically explored. Therefore, we performed [123I]‐FP‐CIT single photon emission computed tomography (SPECT) in 15 patients with very long‐standing PD (mean disease duration 20.6 ± 6.3 years). Measurable uptake of [123I]‐FP‐CIT was still detected in the striata of all patients. As seen in early stages, reduction of tracer uptake in the putamen was more prominent than in the caudate nucleus. Asymmetry in tracer uptake between the two putamen and caudate nuclei was preserved. These findings indicate that degeneration of dopaminergic neurons in PD is not total even after many years of illness. Data should be considered in exploring underlying causes of progressive loss of nigrostriatal dopaminergic neurons and development of future novel dopaminergic therapeutic strategies in PD. © 2010 Movement Disorder Society
Url:
DOI: 10.1002/mds.23380
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000B47
- to stream Istex, to step Curation: 000B47
- to stream Istex, to step Checkpoint: 000140
- to stream PubMed, to step Corpus: 001519
- to stream PubMed, to step Curation: 001519
- to stream PubMed, to step Checkpoint: 001117
- to stream Ncbi, to step Merge: 002E98
- to stream Ncbi, to step Curation: 002E98
- to stream Ncbi, to step Checkpoint: 002E98
- to stream Main, to step Merge: 001461
- to stream PascalFrancis, to step Corpus: 000702
- to stream PascalFrancis, to step Curation: 002616
- to stream PascalFrancis, to step Checkpoint: 000419
- to stream Main, to step Merge: 001A09
- to stream Main, to step Curation: 001408
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Residual striatal dopaminergic nerve terminals in very long‐standing Parkinson's disease: A single photon emission computed tomography imaging study</title><author><name sortKey="Djaldetti, Ruth" sort="Djaldetti, Ruth" uniqKey="Djaldetti R" first="Ruth" last="Djaldetti">Ruth Djaldetti</name></author><author><name sortKey="Lorberboym, Mordechai" sort="Lorberboym, Mordechai" uniqKey="Lorberboym M" first="Mordechai" last="Lorberboym">Mordechai Lorberboym</name></author><author><name sortKey="Karmon, Yuval" sort="Karmon, Yuval" uniqKey="Karmon Y" first="Yuval" last="Karmon">Yuval Karmon</name></author><author><name sortKey="Treves, Therese A" sort="Treves, Therese A" uniqKey="Treves T" first="Therese A." last="Treves">Therese A. Treves</name></author><author><name sortKey="Ziv, Ilan" sort="Ziv, Ilan" uniqKey="Ziv I" first="Ilan" last="Ziv">Ilan Ziv</name></author><author><name sortKey="Melamed, Eldad" sort="Melamed, Eldad" uniqKey="Melamed E" first="Eldad" last="Melamed">Eldad Melamed</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:5C693CED36AE1338303813D404946E7143242745</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1002/mds.23380</idno><idno type="url">https://api.istex.fr/document/5C693CED36AE1338303813D404946E7143242745/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000B47</idno><idno type="wicri:Area/Istex/Curation">000B47</idno><idno type="wicri:Area/Istex/Checkpoint">000140</idno><idno type="wicri:doubleKey">0885-3185:2011:Djaldetti R:residual:striatal:dopaminergic</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:20939078</idno><idno type="wicri:Area/PubMed/Corpus">001519</idno><idno type="wicri:Area/PubMed/Curation">001519</idno><idno type="wicri:Area/PubMed/Checkpoint">001117</idno><idno type="wicri:Area/Ncbi/Merge">002E98</idno><idno type="wicri:Area/Ncbi/Curation">002E98</idno><idno type="wicri:Area/Ncbi/Checkpoint">002E98</idno><idno type="wicri:Area/Main/Merge">001461</idno><idno type="wicri:source">INIST</idno><idno type="RBID">Pascal:11-0188476</idno><idno type="wicri:Area/PascalFrancis/Corpus">000702</idno><idno type="wicri:Area/PascalFrancis/Curation">002616</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000419</idno><idno type="wicri:doubleKey">0885-3185:2011:Djaldetti R:residual:striatal:dopaminergic</idno><idno type="wicri:Area/Main/Merge">001A09</idno><idno type="wicri:Area/Main/Curation">001408</idno><idno type="wicri:Area/Main/Exploration">001408</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Residual striatal dopaminergic nerve terminals in very long‐standing Parkinson's disease: A single photon emission computed tomography imaging study</title><author><name sortKey="Djaldetti, Ruth" sort="Djaldetti, Ruth" uniqKey="Djaldetti R" first="Ruth" last="Djaldetti">Ruth Djaldetti</name><affiliation wicri:level="1"><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Neurology, Rabin Medical Center, Beilinson Campus, Petach Tikva</wicri:regionArea><wicri:noRegion>Petach Tikva</wicri:noRegion></affiliation></author><author><name sortKey="Lorberboym, Mordechai" sort="Lorberboym, Mordechai" uniqKey="Lorberboym M" first="Mordechai" last="Lorberboym">Mordechai Lorberboym</name><affiliation wicri:level="1"><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Nuclear Medicine, Edith Wolfson Medical Center, Holon</wicri:regionArea><wicri:noRegion>Holon</wicri:noRegion></affiliation></author><author><name sortKey="Karmon, Yuval" sort="Karmon, Yuval" uniqKey="Karmon Y" first="Yuval" last="Karmon">Yuval Karmon</name><affiliation wicri:level="1"><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Neurology, Meir Medical Center, Kfar Saba</wicri:regionArea><wicri:noRegion>Kfar Saba</wicri:noRegion></affiliation></author><author><name sortKey="Treves, Therese A" sort="Treves, Therese A" uniqKey="Treves T" first="Therese A." last="Treves">Therese A. Treves</name><affiliation wicri:level="1"><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Neurology, Rabin Medical Center, Beilinson Campus, Petach Tikva</wicri:regionArea><wicri:noRegion>Petach Tikva</wicri:noRegion></affiliation></author><author><name sortKey="Ziv, Ilan" sort="Ziv, Ilan" uniqKey="Ziv I" first="Ilan" last="Ziv">Ilan Ziv</name><affiliation wicri:level="1"><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Neurology, Rabin Medical Center, Beilinson Campus, Petach Tikva</wicri:regionArea><wicri:noRegion>Petach Tikva</wicri:noRegion></affiliation></author><author><name sortKey="Melamed, Eldad" sort="Melamed, Eldad" uniqKey="Melamed E" first="Eldad" last="Melamed">Eldad Melamed</name><affiliation wicri:level="1"><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Neurology, Rabin Medical Center, Beilinson Campus, Petach Tikva</wicri:regionArea><wicri:noRegion>Petach Tikva</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Israël</country><wicri:regionArea>Norma and Alan Aufzien Chair for Research of Parkinson's Disease, Tel Aviv University, Sackler School of Medicine Tel Aviv</wicri:regionArea><wicri:noRegion>Sackler School of Medicine Tel Aviv</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-02-01">2011-02-01</date><biblScope unit="vol">26</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="327">327</biblScope><biblScope unit="page" to="330">330</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">5C693CED36AE1338303813D404946E7143242745</idno><idno type="DOI">10.1002/mds.23380</idno><idno type="ArticleID">MDS23380</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Brain (metabolism)</term><term>Brain (radionuclide imaging)</term><term>Dopamine</term><term>Dopamine (metabolism)</term><term>Dopamine Plasma Membrane Transport Proteins (metabolism)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Nerve Endings (metabolism)</term><term>Nerve Endings (radionuclide imaging)</term><term>Nervous system diseases</term><term>Neurons (metabolism)</term><term>Neurons (radionuclide imaging)</term><term>Parkinson Disease (metabolism)</term><term>Parkinson Disease (radionuclide imaging)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Single photon emission tomography</term><term>Tomography, Emission-Computed, Single-Photon</term><term>dopamine transporters scan</term><term>long standing</term><term>single photon emission computed tomography</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine</term><term>Dopamine Plasma Membrane Transport Proteins</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Brain</term><term>Nerve Endings</term><term>Neurons</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Brain</term><term>Nerve Endings</term><term>Neurons</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Dopamine</term><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Tomoscintigraphie émission monophotonique</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Molecular imaging studies of Parkinson's disease (PD) progression mostly focus on the first 5 years after disease onset, demonstrating rapid initial nigrostriatal neuronal loss. The fate of residual functional dopaminergic nerve terminals in patients with long‐standing PD has not yet been specifically explored. Therefore, we performed [123I]‐FP‐CIT single photon emission computed tomography (SPECT) in 15 patients with very long‐standing PD (mean disease duration 20.6 ± 6.3 years). Measurable uptake of [123I]‐FP‐CIT was still detected in the striata of all patients. As seen in early stages, reduction of tracer uptake in the putamen was more prominent than in the caudate nucleus. Asymmetry in tracer uptake between the two putamen and caudate nuclei was preserved. These findings indicate that degeneration of dopaminergic neurons in PD is not total even after many years of illness. Data should be considered in exploring underlying causes of progressive loss of nigrostriatal dopaminergic neurons and development of future novel dopaminergic therapeutic strategies in PD. © 2010 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Israël</li></country></list><tree><country name="Israël"><noRegion><name sortKey="Djaldetti, Ruth" sort="Djaldetti, Ruth" uniqKey="Djaldetti R" first="Ruth" last="Djaldetti">Ruth Djaldetti</name></noRegion><name sortKey="Karmon, Yuval" sort="Karmon, Yuval" uniqKey="Karmon Y" first="Yuval" last="Karmon">Yuval Karmon</name><name sortKey="Lorberboym, Mordechai" sort="Lorberboym, Mordechai" uniqKey="Lorberboym M" first="Mordechai" last="Lorberboym">Mordechai Lorberboym</name><name sortKey="Melamed, Eldad" sort="Melamed, Eldad" uniqKey="Melamed E" first="Eldad" last="Melamed">Eldad Melamed</name><name sortKey="Melamed, Eldad" sort="Melamed, Eldad" uniqKey="Melamed E" first="Eldad" last="Melamed">Eldad Melamed</name><name sortKey="Treves, Therese A" sort="Treves, Therese A" uniqKey="Treves T" first="Therese A." last="Treves">Therese A. Treves</name><name sortKey="Ziv, Ilan" sort="Ziv, Ilan" uniqKey="Ziv I" first="Ilan" last="Ziv">Ilan Ziv</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001408 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001408 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:5C693CED36AE1338303813D404946E7143242745
|texte= Residual striatal dopaminergic nerve terminals in very long‐standing Parkinson's disease: A single photon emission computed tomography imaging study
}}
| This area was generated with Dilib version V0.6.23. |  |